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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
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research activity
  • oligosaccharide synthesis
  • neoglycoconjugates
  • glycoarrays
  • supramolecular chemistry
  • influenza
  • transplantology and blood groups
  • oncology
  • natural antibodies
  • glycotargeting
  • Our lab has developed a glycan microarray (printed glycan array, PGA) in cooperation with the Consortium for Functional Glycomics
    Glycoarray design
    Glycoarray is a glass or plastic slide 25 × 75 mm (1 × 3 inches). Ligands are immobilized on its surface as the spots having the diameter ~100 µm.
    Its plastic version is under development by Semiotik LLC as key platform for cancer diagnostics and reproduction desiases.

    It is possible to apply thousands of various ligands to the surface of the slide. The latest version of the glycoarray includes ~400 synthetic oligosaccharides and ~200 bacterial polysaccharides (kindly provided by Prof. Yu.A. Knirel, Zelinsky Institute of Organic Chemistry). Each substance is printed in six replicates.
    PGA ligands
    Glycans (oligosaccharides)

    Bacterial polysaccharides (O-antigens, LPS)
    Glycoarray deals excellently with the following tasks:
    Scheme of glycoarray assay is analogous to ELISA: