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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
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research activity
  • oligosaccharide synthesis
  • neoglycoconjugates
  • glycoarrays
  • supramolecular chemistry
  • influenza
  • transplantology and blood groups
  • oncology
  • natural antibodies
  • glycotargeting
  • It is generally accepted that the generation of antibodies proceeds due to immunization of an organism by alien antigens, and the level and affinity of antibodies are directly correlated to the presence of immunogen. At the same time, mumerous experimental data provide evidence of antibodies whose level remains unchanged and affinity is constant during a lifetime. In contrast to the first, adaptive immunoglobulins, the latter are named natural antibodies (nAbs). The nAbs are produced by B1 cells, whereas adaptive Abs are produced by B2. Using printed glycan array (PGA) we identified big number of nAbs not described earlier, including cancer-associated anti-LeC. We use hapten-specific affinity chromatography for isolation of human and mammalian nAbs with subsecuent PGA analysis for investigation of their fine epitope specificity. Using mice model we study genesis of nAbs and role of microbiota in the genesis and regulation of nAbs.