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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
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research activity
  • oligosaccharide synthesis
  • neoglycoconjugates
  • glycoarrays
  • supramolecular chemistry
  • influenza
  • transplantology and blood groups
  • oncology
  • natural antibodies
  • glycotargeting
  • Supramolecular chemistry: synthesis of self-assembling peptides and glycopeptides
    The interest to small molecule self-assembling is caused to high extent by the possibility to design nanomaterials with The interest to small molecule self-assembling is caused to high extent by the possibility to design nanomaterials with customized properties and molecular devices. The driving force of self-assembling is simultaneous formation of multiple hydrogen bonds between complementary fragments. Our goal was the design of non-covalent polymers, (Glycosyl-Z)n, where Z fragment provides the assembling, soluble and stable in aqueous solution. We expected that the supramers could display sharply increased activity due to multivalent display of Glycosyl functionality When synthesizing oligovalent glycopeptides, [glycinen-NHCH2]4C, we have observed that some of them possess the required properties, i.e. form supramers that are stable in aqueous solutions. Oligopeptide chains (glycosyl free) are joined in the supramers by polyglycine II type, forming water insoluble flat sheets of submicron size, one molecule thick (~50Å). Reversible disassembling takes place in concentrated solution of lithium bromide, trifluoroacetic acid, or upon heating. Due to rigidity, regulated thickness, NH2functionality, and reversibility of self-assembly obtained material is prospective as atomically smooth platform for nano-device engineering.